HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → methyl 13-cyclohexyl-7H-indolo[2,1-a][2]benzazepine-10-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | methyl 1-allyl-3-cyclohexyl-2-(2-vinylphenyl)1H-indole-6-carboxylate | HCID 58765270 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | methyl 13-cyclohexyl-7H-indolo[2,1-a][2]benzazepine-10-carboxylate | HCID 11667856 | 84% |
Reaction Steps
Crude methyl 1-allyl-3-cyclohexyl-2-(2-vinylphenyl)1H-indole-6-carboxylate was dissolved in DCM (0.02M) and treated with Zhan catalyst I (0.3 eq) at 35° C. for 1 h. NEt3 (7 eq) were added and the solvent was removed in vacuo. The residue was purified by chromatography (PE/EtOAc 95:5) to afford the title compound (84%); MS (ES+) m/z 372 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07662809B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-ca16578ddb8047349ba56253d72f05d2 |
| Source note | uspto-grants-2010_02 |