huagongshe.com
HRID1444619

反应详情

EQUATION

反应方程式

HRID 1444619 的结构方程式

REACTANTS

反应物

2
结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：C=CCn1c(-c2ccccc2C=C)c(C2CCCCC2)c2ccc(C(=O)OC)cc21
HCID58765270

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CC=Cc1ccccc1-3
HCID11667856

未命名化合物

收率 84%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Crude methyl 1-allyl-3-cyclohexyl-2-(2-vinylphenyl)1H-indole-6-carboxylate was dissolved in DCM (0.02M) and treated with Zhan catalyst I (0.3 eq) at 35° C. for 1 h. NEt3 (7 eq) were added and the solvent was removed in vacuo. The residue was purified by chromatography (PE/EtOAc 95:5) to afford the title compound (84%); MS (ES+) m/z 372 (M+H)+.

WORKUP

后处理

  1. customthe solvent was removed in vacuo
  2. customThe residue was purified by chromatography (PE/EtOAc 95:5)