反应详情

To a solution of N-[2-(4-chloromethyl-phenyl)-ethyl]-2-[3-oxo-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-pyrazin-2-yl]-acetamide (195 mg, 0.42 mmol) in CH2Cl2 (2 mL) was added piperidine (Aldrich, 0.13 mL, 1.3 mmol) at rt. The reaction mixture was stirred at rt overnight and then diluted with CH2Cl2 (50 mL). The organic solution was washed with saturated NaHCO3, and brine, dried over Na2SO4, filtered and concentrated in vacuo. Purification by preparative TLC (7% MeOH—CH2Cl2) afforded the title compound. MS (ESI): 511 (M+H)+.

1. washThe organic solution was washed with saturated NaHCO3, and brine
2. dry with materialdried over Na2SO4
3. filtrationfiltered
4. concentrationconcentrated in vacuo
5. customPurification by preparative TLC (7% MeOH—CH2Cl2)