反应详情

温度

92.5 °C

40 ml of 2,3-dimethyl-4-(2,2,2-trifluoroethoxy)pyridine N-oxide (0.078 mole) in methylene chloride were dropwise added to a solution of 28.7 ml acetanhydride and 0.182 g 4-dimethylaminopyridine, then methylene chloride was distilled off and the residue was heated to a temperature of from 90 to 95° C. for 4-5 hours. At the end of the reaction, 3.6 ml of water were added and acetic acid was removed by vacuum distillation to obtain an oil product. The yield was 94-96%, determined by HPLC.

1. distillationmethylene chloride was distilled off
2. customAt the end of the reaction, 3.6 ml of water
3. additionwere added
4. customacetic acid was removed by vacuum distillation
5. customto obtain an oil product