反应详情

温度

80 °C

3-(5-Ammoniopentanoyl)pyridinium chloride (162 mg, 0.64 mmol) was suspended in a reaction vessel with i-propanol (12 mL). 3-(4-chlorophenoxy)benzaldehyde (225 mg, 0.97 mmol) was then added and the reaction vessel sealed. The reaction was heated to 80° C. overnight and then cooled to room temperature. The precipitate was recovered by vacuum filtration, washed with a 20% i-propanol in hexane solution then dried under vacuum giving 161 mg (56%) of a tan-colored solid. LC-MS: RT=6.22 min, [M+H]+=375.1.

1. customthe reaction vessel sealed
2. temperaturecooled to room temperature
3. filtrationThe precipitate was recovered by vacuum filtration
4. washwashed with a 20% i-propanol in hexane solution
5. customthen dried under vacuum