反应详情

温度

80 °C

3-(5-Ammoniopentanoyl)pyridinium chloride (101 mg, 0.40 mmol) and 6-phenoxynicotinaldehyde (120 mg, 0.60 mmol) were combined in a reaction vessel and treated with isopropanol (15 mL). The reaction vessel was sealed and the reaction was heated to 80° C. with stirring overnight. The reaction was then cooled to room temperature. The precipitate that formed was recovered by vacuum filtration and washed with a 20% solution of isopropanol in hexane and then with ether. The recovered solid was then dried under vacuum giving 122 mg (73%) of a pale yellow solid. LC-MS: RT=5.08 min, [M+H]+=342.1.

1. customThe reaction vessel was sealed
2. temperatureThe reaction was then cooled to room temperature
3. customThe precipitate that formed
4. filtrationwas recovered by vacuum filtration
5. washwashed with a 20% solution of isopropanol in hexane
6. customThe recovered solid was then dried under vacuum