反应详情

185 mg of the compound from Example 14A (0.38 mol) are dissolved in 6 ml of THF/methanol (1:1) and 1 ml of 1 N sodium hydroxide solution is added. The reaction mixture is stirred at room temperature for 16 h. It is diluted with water and acidified with 2 N hydrochloric acid, and the mixture is extracted three times with dichloromethane. The combined organic phases are dried over sodium sulphate and concentrated in a rotary evaporator. 172 mg (99% of theory) of the title compound are obtained.

1. extractionthe mixture is extracted three times with dichloromethane
2. dry with materialThe combined organic phases are dried over sodium sulphate
3. concentrationconcentrated in a rotary evaporator