反应详情

85 mg of the compound from Example 23A (0.19 mol) are dissolved in 3.5 ml of dioxane/water (1:1) and mixed with 0.29 ml of 1 N sodium hydroxide solution (0.29 mol). The reaction mixture is stirred at room temperature for 3 h. It is acidified with 5 ml of 1 N hydrochloric acid, and the mixture is extracted three times with dichloromethane. The combined organic phases are dried over sodium sulphate and concentrated in a rotary evaporator. 80 mg (100% of theory) of the title compound are obtained.

1. extractionthe mixture is extracted three times with dichloromethane
2. dry with materialThe combined organic phases are dried over sodium sulphate
3. concentrationconcentrated in a rotary evaporator