反应详情

A solution of 2-methyl-3-nitropyridine (10.155 g, 72.46 mmol) prepared in Step 1 of Preparation 1 and selenium dioxide (8.84 g, 79.71 mmol) in 1,4-dioxane (80 ml) was refluxed for 2 days. The reaction mixture was cooled to room temperature, filtered, and then concentrated under reduced pressure. The resulting residue was purified with silica gel column chromatography (ethyl acetate/n-hexane=1/2, v/v) to give 12.8 g of the titled compound as red oil.

1. temperaturewas refluxed for 2 days
2. filtrationfiltered
3. concentrationconcentrated under reduced pressure
4. customThe resulting residue was purified with silica gel column chromatography (ethyl acetate/n-hexane=1/2, v/v)