Benzyl Bromide → HCID 86615268, compound

HRID 1445121Notes

Reaction equation

[C:1]([O:5][C:6](=[O:28])[N:7]([C:16]1[N:17]=[C:18]([Cl:27])[CH:19]=[C:20]2[C:24]([CH3:25])=[C:23]([CH3:26])[NH:22][C:21]=12)[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[CH2:29](Br)[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>>[C:1]([O:5][C:6](=[O:28])[N:7]([C:16]1[N:17]=[C:18]([Cl:27])[CH:19]=[C:20]2[C:24]([CH3:25])=[C:23]([CH3:26])[N:22]([CH2:29][C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[C:21]=12)[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 7498Benzyl Bromide

HCID 86615269HCID 86615269, compound

Product 1

HCID 86615268HCID 86615268, compoundYield 70%

Procedure

In accordance with the same procedures as in Example 657, except for using (5-chloro-2,3-dimethyl-1H-pyrrolo[2,3-c]pyridin-7-yl)-(4-fluorobenzyl)-carbamic acid tert-butyl ester prepared in Step 2 and benzyl bromide, the titled compound was obtained as yellow oil. (Yield: 70%)

Sources & evidence

ORD record: ord-6faab11bfe7e4bf8b75fa80d8bd79cd1
Source dataset: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07662832B2

Reaction notes

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