1-Ethylpiperazine → HCID 67142046, compound

HRID 1445138Notes

Reaction equation

[CH2:1]([N:4]1[C:8]2=[C:9]([N:16]3[CH2:25][CH2:24][C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[CH2:17]3)[N:10]=[C:11]([C:13]([OH:15])=O)[CH:12]=[C:7]2[CH:6]=[C:5]1[CH3:26])[CH:2]=[CH2:3].[CH2:27]([N:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1)[CH3:28]>>[CH2:1]([N:4]1[C:8]2=[C:9]([N:16]3[CH2:25][CH2:24][C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[CH2:17]3)[N:10]=[C:11]([C:13]([N:32]3[CH2:33][CH2:34][N:29]([CH2:27][CH3:28])[CH2:30][CH2:31]3)=[O:15])[CH:12]=[C:7]2[CH:6]=[C:5]1[CH3:26])[CH:2]=[CH2:3]

Participants

Reactant 2

HCID 791961-Ethylpiperazine

HCID 67142168HCID 67142168, compound

Product 1

HCID 67142046HCID 67142046, compoundYield 49%

Procedure

In accordance with the same procedures as in Step 1 of Example 756, except for using 1-allyl-7-(3,4-dihydro-1H-isoquinolin-2-yl)-2-methyl-1H-pyrrolo[2,3-c]pyridin-5-carboxylic acid prepared in Step 1 of Example 922 and 1-ethylpiperazine, the titled compound was obtained as a white solid. (Yield: 49%)

Sources & evidence

ORD record: ord-c43fc60ad8f8481f91d86fe3d787d9b1
Source dataset: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07662832B2

Reaction notes

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