Phosphorus oxychloride → 3-Chloro-5-phenyl-pyridazine-4-carbonitrile

HRID 1445301Notes

Reaction equation

HRID 1445301 reaction equation
O=[C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:5]=[N:4][NH:3]1.P(Cl)(Cl)([Cl:18])=O>>[Cl:18][C:2]1[N:3]=[N:4][CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:7]=1[C:8]#[N:9]

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 597350963-Oxo-5-phenyl-2,3-dihydro-pyridazine-4-carbonitrile

Product 1

HCID 597350973-Chloro-5-phenyl-pyridazine-4-carbonitrile

Conditions

Temperature
100 °C

Procedure

3-Oxo-5-phenyl-2,3-dihydro-pyridazine-4-carbonitrile (70 mg) was suspended in 1 mL phosphorous oxychloride and heated to 100° C. for 6 hours. The mixture was then cooled and poured onto ice. The resulting brown solid product was filtered and air dried and used in the next step without further purification.

Workup

  1. temperatureThe mixture was then cooled
  2. additionpoured onto ice
  3. filtrationThe resulting brown solid product was filtered
  4. customair dried
  5. customused in the next step without further purification

Sources & evidence

ORD record
ord-bd5e34d29f394ea2bd540100a0cf9937
Source dataset
uspto-grants-2010_02
Patent number
US07666647B2

Reaction notes

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