反应详情

温度

22 °C

1.44 g of 3-hydroxy-thiophene-2-carboxylic acid were dissolved in 100 ml of dichloromethane, and 2.18 ml of benzylamine and 5.00 ml of a 50% strength 1-propanephosphoric anhydride solution in acetic acid were added. The reaction mixture was stirred at 22° C. for 2 h and, after addition of 100 ml of saturated sodium bicarbonate solution, extracted twice with 100 ml of dichloromethane each time. The combined organic phases were washed with 100 ml of saturated sodium chloride solution, dried over magnesium sulfate and concentrated. The product with the molecular weight of 233.3 (C12H11NO2S), MS (ESI): 234 (M+h+) was obtained.

1. extractionextracted twice with 100 ml of dichloromethane each time
2. washThe combined organic phases were washed with 100 ml of saturated sodium chloride solution
3. dry with materialdried over magnesium sulfate
4. concentrationconcentrated
5. customThe product with the molecular weight of 233.3 (C12H11NO2S), MS (ESI): 234 (M+h+) was obtained