Hydrochloric Acid → HCID 21961219, compound

HRID 1445341Notes

Reaction equation

HRID 1445341 reaction equation
C([O:4][CH2:5][CH:6]1[CH:11]([O:12]C(=O)C)[CH:10]([O:16]C(=O)C)[CH:9]([O:20]C(=O)C)[CH:8]([O:24][C:25]2[CH:29]=[CH:28][S:27][C:26]=2[C:30](=[O:39])[NH:31][CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[O:7]1)(=O)C.C[O-].[Na+].Cl>CO>[CH2:32]([NH:31][C:30]([C:26]1[S:27][CH:28]=[CH:29][C:25]=1[O:24][CH:8]1[CH:9]([OH:20])[CH:10]([OH:16])[CH:11]([OH:12])[CH:6]([CH2:5][OH:4])[O:7]1)=[O:39])[C:33]1[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 10942334Sodium MethoxideHCID 21961241HCID 21961241, compound

Product 1

HCID 21961219HCID 21961219, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
22 °C

Procedure

600 mg of 3,4,5-triacetoxy-6-(2-benzylcarbamoyl-thiophen-3-yloxy)-tetrahydro-pyran-2-ylmethyl acetate were dissolved in 40 ml of methanol, and 1.40 ml of a 30% strength methanolic sodium methanolate solution were added. The reaction mixture was stirred at 22° C. for 2 h, neutralized with 0.5 molar methanolic HCl solution and concentrated. The crude product was purified by column chromatography (SiO2, ethyl actate/methanol=10:1).

Workup

  1. concentrationconcentrated
  2. customThe crude product was purified by column chromatography (SiO2, ethyl actate/methanol=10:1)

Sources & evidence

ORD record
ord-9619e37dcf074b51ab413ed9dde5a792
Source dataset
uspto-grants-2010_02
Patent number
US07666848B2

Reaction notes

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