HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1445420Generated: November 3, 2026
Trifluoroacetic acid → 1-[(4-Hydroxy-pyrrolidine-2-carbonyl)-amino]-2-vinyl-cyclopropanecarboxylic acid ethyl ester
https://huagongshe.com/reaction/1445420
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 2-(1-Ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 23571603 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-[(4-Hydroxy-pyrrolidine-2-carbonyl)-amino]-2-vinyl-cyclopropanecarboxylic acid ethyl ester | HCID 66871268 | — |
Reaction Steps
Compound 122 (10.5 g, 28.4 mmol) was dissolved in DCM (70 ml) and cooled to 0° C., TFA (35 ml) was added. After appr 1 h the solution was evaporated and neutralized with aqueous sodium carbonate and evaporated on silica. Purification of the crude product by column chromatography on silica (MeOH/DCM: 15/85) gave 9.7 g of still unpure compound title compound. This material was used in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07666834B2 |
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| Source dataset | uspto-grants-2010_02 |
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| ORD ID | ord-95aba84575fd4219bb7b922eeda5e7d6 |
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| Source note | uspto-grants-2010_02 |
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