反应详情

温度

0 °C

Compound 122 (10.5 g, 28.4 mmol) was dissolved in DCM (70 ml) and cooled to 0° C., TFA (35 ml) was added. After appr 1 h the solution was evaporated and neutralized with aqueous sodium carbonate and evaporated on silica. Purification of the crude product by column chromatography on silica (MeOH/DCM: 15/85) gave 9.7 g of still unpure compound title compound. This material was used in the next step.

1. customthe solution was evaporated
2. customevaporated on silica
3. customPurification of the crude product by column chromatography on silica (MeOH/DCM: 15/85)