HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 18-(tert-Butyl-dimethyl-silanyloxy)-14-(4-methoxy-benzyl)-2,15-dioxo-3,14,16-triaza-tricyclo[14.3.0.0*4,6*]nonadec-7-ene-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | 18-(tert-Butyl-dimethyl-silanyloxy)-14-(4-methoxy-benzyl)-2,15-dioxo-3,14,16-triaza-tricyclo[14.3.0.0*4,6*]nonadec-7-ene-4-carboxylic acid ethyl ester | HCID 66871346 | — |
| Solvent | Methanol tetrahydrofuran water | HCID 21892291 | — |
| Product | 18-(tert-Butyl-dimethyl-silanyloxy)-14-(4-methoxy-benzyl)-2,15-dioxo-3,14,16-triaza-tricyclo[14.3.0.0*4,6*]nonadec-7-ene-4-carboxylic acid | HCID 68677699 | 75% |
Reaction Steps
Compound 126 (450 mg, 0.734 mmol) was dissolved in THF/MeOH/H2O (2:1:1). LiOH, 1M (7.4 ml, 7.4 mmol) was added and the reaction mixture was allowed to stir at RT over night. Acidification (5% citric acid) followed by extraction with chloroform gave the title compound (321 mg, 75%). M+H=586.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07666834B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-88baba3737e04711b9e71d1acbef9599 |
| Source note | uspto-grants-2010_02 |