HRID1445424

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3939

Lithium hydroxide anhydrous

HLiO

结构：CCOC(=O)C12CC1C=CCCCCCN(Cc1ccc(OC)cc1)C(=O)N1CC(O[Si](C)(C)C(C)(C)C)CC1C(=O)N2

HCID66871346

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(CN2CCCCCC=CC3CC3(C(=O)O)NC(=O)C3CC(O[Si](C)(C)C(C)(C)C)CN3C2=O)cc1

HCID68677699

未命名化合物

收率 75%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21892291

未命名化合物

PROCEDURE

实验过程

Compound 126 (450 mg, 0.734 mmol) was dissolved in THF/MeOH/H2O (2:1:1). LiOH, 1M (7.4 ml, 7.4 mmol) was added and the reaction mixture was allowed to stir at RT over night. Acidification (5% citric acid) followed by extraction with chloroform gave the title compound (321 mg, 75%). M+H=586.

WORKUP

后处理

extractionAcidification (5% citric acid) followed by extraction with chloroform

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-88baba3737e04711b9e71d1acbef9599
来源数据集: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07666834B2
来源说明: uspto-grants-2010_02

反应 SMILES

C([O:3][C:4]([C:6]12[CH2:24][CH:23]1[CH:22]=[CH:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][N:15]([CH2:25][C:26]1[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][CH:27]=1)[C:14](=[O:34])[N:13]1[CH:9]([CH2:10][CH:11]([O:35][Si:36]([C:39]([CH3:42])([CH3:41])[CH3:40])([CH3:38])[CH3:37])[CH2:12]1)[C:8](=[O:43])[NH:7]2)=[O:5])C.[Li+].[OH-]>C1COCC1.CO.O>[C:39]([Si:36]([CH3:38])([CH3:37])[O:35][CH:11]1[CH2:10][CH:9]2[N:13]([C:14](=[O:34])[N:15]([CH2:25][C:26]3[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][CH:27]=3)[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH:21]=[CH:22][CH:23]3[C:6]([C:4]([OH:5])=[O:3])([NH:7][C:8]2=[O:43])[CH2:24]3)[CH2:12]1)([CH3:42])([CH3:41])[CH3:40]