2-Bromoaniline → HCID 18369533, compound

HRID 1445432Notes

Reaction equation

C([Sn](CCCC)(CCCC)[C:6]1[S:7][CH:8]=[CH:9][N:10]=1)CCC.Br[C:20]1[CH:26]=[CH:25][CH:24]=[CH:23][C:21]=1[NH2:22]>>[S:7]1[CH:8]=[CH:9][N:10]=[C:6]1[C:20]1[CH:26]=[CH:25][CH:24]=[CH:23][C:21]=1[NH2:22]

Participants

Reactant 2

HCID 119922-Bromoaniline

HCID 27632592-(Tributylstannyl)-1,3-thiazole

Product 1

HCID 18369533HCID 18369533, compoundYield 25%

Procedure

2-Tributylstannanyl-thiazole (600 mg, 1.6 mmol) was reacted with 2-bromoaniline (200 mg, 1.2 mmol) according to general procedure [B] for the preparation of substituted anilines described above, which gave the title compound (51 mg, 25%). [M+1] 177.

Sources & evidence

ORD record: ord-face8b88aba04595b923c52cddc88598
Source dataset: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07666834B2

Reaction notes

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