反应详情

N1-[2-[2-(tert-Butoxycarbonylamino)ethoxy]-4-methoxybenzoyl]-N2-(4-methoxybenzoyl)-1,2-benzenediamine (124 mg, 231 μmol) was dissolved in 3 ml of neat trifluoroacetic acid (TFA) in a capped vial for 90 min at room temperature. The volatiles were removed in vacuo and the residue was resuspended in a few ml of toluene and re-evaporated. This step was repeated twice more with toluene and once with dichloromethane. The resulting white solid was dried under high vacuum to give 113 mg (89%) of N1-[2-(2-aminoethoxy)-4-methoxybenzoyl]-N2-(4-methoxybenzoyl)-1,2-benzenediamine trifluoroacetate as a solid white film.

1. customThe volatiles were removed in vacuo
2. customre-evaporated
3. customThe resulting white solid was dried under high vacuum