Hydrochloric Acid → Dextrose mannitol

Participants

Reaction Steps

Solutions containing pectin (Slendid 100) (20 mg/ml) were prepared at pH 3, 4, 5 and 6 (pH adjustments were made with 0.1M HCl or 0.1M meglumine). Into 5 ml of each solution was dissolved 0, 62.5, 125, 187.5 or 200 mg anhydrous dextrose or mannitol to give approximate dextrose/mannitol concentrations of 0, 12.5, 25, 37.5 or 50 mg/ml respectively. An excess of buprenorphine hydrochloride was then added and the mixture stirred overnight at 18° C. Saturated buprenorphine hydrochloride solutions were produced by passing each mixture through a 0.2 μm polycarbonate membrane filter. The concentration of buprenorphine hydrochloride in the filtrate was determined by hplc.

Provenance & Evidence