反应详情

Into 15 ml of pyridine was dissolved 3.00 g of 6-(trifluoromethyl)pyridin-3-amine, and then 2.1 ml of methyl chloroformate was added thereto under ice-cooling, followed by 2 hours of stirring at room temperature. Under ice-cooling, 30 ml of a saturated sodium bicarbonate aqueous solution was added to the reaction solution, followed by 1 hour of stirring. Thereafter, the precipitated crystals were filtrated and, after washing with water, dried under reduced pressure to obtain 3.88 g of the title compound.

1. temperatureunder ice-cooling
2. temperatureUnder ice-cooling
3. waitfollowed by 1 hour
4. stirringof stirring
5. filtrationThereafter, the precipitated crystals were filtrated
6. washafter washing with water
7. customdried under reduced pressure