Hydrochloric Acid → HCID 15986052, compound

HRID 1445485Notes

Reaction equation

HRID 1445485 reaction equation
[CH3:1][S:2]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:12]1[CH:17]=[CH:16][C:15]([S:18]([N:21]2[CH:25]=[CH:24][C:23](/[CH:26]=[CH:27]/[C:28]([NH:30][O:31]C3CCCCO3)=[O:29])=[CH:22]2)(=[O:20])=[O:19])=[CH:14][CH:13]=1)(=[O:4])=[O:3].Cl>CO>[OH:31][NH:30][C:28](=[O:29])/[CH:27]=[CH:26]/[C:23]1[CH:24]=[CH:25][N:21]([S:18]([C:15]2[CH:14]=[CH:13][C:12]([C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=3[NH:5][S:2]([CH3:1])(=[O:4])=[O:3])=[CH:17][CH:16]=2)(=[O:19])=[O:20])[CH:22]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86621686HCID 86621686, compound

Product 1

HCID 15986052HCID 15986052, compoundYield 43.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 0.220 g (E)-3-[1-(2′-methanesulfonylamino-biphenyl-4-sulfonyl)-1H-pyrrol-3-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide with 6.0 ml methanol and 13.0 ml 1M aqueous HCl is stirred at ambient temperature for 24 h. During evaporation the product starts to crystallize. The crystals are washed with water and diisopropylether. The crude product is purified by PLC plates chromatography. By this method 0.081 g of a red oil are obtained.

Workup

  1. customDuring evaporation the product
  2. customto crystallize
  3. washThe crystals are washed with water and diisopropylether
  4. customThe crude product is purified by PLC plates chromatography

Sources & evidence

ORD record
ord-95a2bf8a88e74a3381c665dff2e0635a
Source dataset
uspto-grants-2010_02
Patent number
US07666868B2

Reaction notes

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