反应详情

A mixture of 0.4 g (E)-3-[1-(4-Bromo-benzenesulfonyl)-1H-pyrrol-3-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide, 0.231 g N-Methylindol-5-boronic acid and 14 ml dimethoxyethane is slightly heated and to this mixture are added bis(triphenylphosphine)palladium(II)chloride and 1.5 ml of a 2M aqueous sodium sulfate solution. This mixture is heated to reflux temperature under an inert gas atmosphere overnight. After cooling the mixture is filtered, evaporated and the residue is partitioned between ethyl acetate and a 5% aqueous solution of sodium bicarbonate. The organic phase is dried and evaporated and the residue is purified by silica gel flash chromatography.

1. temperatureis slightly heated and to this mixture
2. temperatureThis mixture is heated
3. temperatureto reflux temperature under an inert gas atmosphere overnight
4. temperatureAfter cooling the mixture
5. filtrationis filtered
6. customevaporated
7. customthe residue is partitioned between ethyl acetate
8. customThe organic phase is dried
9. customevaporated
10. customthe residue is purified by silica gel flash chromatography