Trifluoroacetic acid → HCID 68525252, compound

HRID 1445510Notes

Reaction equation

HRID 1445510 reaction equation
C([O:5][C:6](=[O:23])/[CH:7]=[CH:8]/[C:9]1[CH:13]=[CH:12][N:11]([S:14]([C:17]2[S:18][C:19]([Br:22])=[CH:20][CH:21]=2)(=[O:16])=[O:15])[CH:10]=1)(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[Br:22][C:19]1[S:18][C:17]([S:14]([N:11]2[CH:12]=[CH:13][C:9](/[CH:8]=[CH:7]/[C:6]([OH:23])=[O:5])=[CH:10]2)(=[O:15])=[O:16])=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68527901HCID 68527901, compound

Product 1

HCID 68525252HCID 68525252, compoundYield 97.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 4.5 g (E)-3-[1-(5-bromo-thiophene-2-sulfonyl)-1H-pyrrol-3-yl]-acrylic acid tert-butyl ester with 85.0 ml dichloromethane and 13.0 ml TFA is stirred at ambient temperature for 24 h. The dichloromethane and TFA is evaporated and the residue is coevaporated with toluene for 3 times. By this method 3.8 g light pink solid is obtained.

Workup

  1. customThe dichloromethane and TFA is evaporated

Sources & evidence

ORD record
ord-f2219a014e904152bbfcafb702b85023
Source dataset
uspto-grants-2010_02
Patent number
US07666868B2

Reaction notes

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