Dichloromethane → HCID 57731174, compound

HRID 1445698Notes

Reaction equation

HRID 1445698 reaction equation
ClCCl.[F:4][C:5]1[C:15]([N:16]2[C:20](=[O:21])[N:19]([CH3:22])[C:18]([CH3:23])=[N:17]2)=[CH:14][C:8]2[N:9]=[C:10]([S:12][CH3:13])[S:11][C:7]=2[CH:6]=1.ClC1C=C(C=CC=1)C(OO)=[O:29]>O>[F:4][C:5]1[C:15]([N:16]2[C:20](=[O:21])[N:19]([CH3:22])[C:18]([CH3:23])=[N:17]2)=[CH:14][C:8]2[N:9]=[C:10]([S:12]([CH3:13])=[O:29])[S:11][C:7]=2[CH:6]=1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 70297m-Chloroperbenzoic acidHCID 68544822HCID 68544822, compound

Product 1

HCID 57731174HCID 57731174, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

10 mL dichloromethane was charged with 0.001 mol 1-(6-fluoro-2-(methylthio)benzo[d]thiazol-5-yl)-3,4-dimethyl-1H-1,2,4-triazol-5(4H)-one. The mixture was stirred for 10 mins and then 0.0011 mol m-chloroperoxybenzoic acid (MCPBA) were added. After stirring at room temperature for 2 hours, the mixture was poured into 30 mL of water, extracted with 15 mL dichloromethane twice. Organic phases were combined and dried over anhydrous sodium sulfate. Filtration and removal of solvent under vacuum gave the title compound as a white solid in a 93% yield.

Workup

  1. stirringAfter stirring at room temperature for 2 hours
  2. extractionextracted with 15 mL dichloromethane twice
  3. dry with materialdried over anhydrous sodium sulfate
  4. filtrationFiltration and removal of solvent under vacuum

Sources & evidence

ORD record
ord-e295ba7baea941e0847af9863953748a
Source dataset
uspto-grants-2010_02
Patent number
US07666890B2

Reaction notes

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