Water → HCID 57731180, compound

HRID 1445700Notes

Reaction equation

HRID 1445700 reaction equation
ClCCl.[F:4][C:5]1[C:17]([N:18]2[C:22](=[O:23])[N:21]([CH3:24])[C:20]([CH3:25])=[N:19]2)=[CH:16][C:8]2[N:9]=[C:10]([S:12][CH2:13][CH2:14][CH3:15])[S:11][C:7]=2[CH:6]=1.ClC1C=C(C=CC=1)C(OO)=[O:31].[OH2:37]>>[F:4][C:5]1[C:17]([N:18]2[C:22](=[O:23])[N:21]([CH3:24])[C:20]([CH3:25])=[N:19]2)=[CH:16][C:8]2[N:9]=[C:10]([S:12]([CH2:13][CH2:14][CH3:15])(=[O:31])=[O:37])[S:11][C:7]=2[CH:6]=1

Participants

5

Reactant 4

HCID 962WaterHCID 6344DichloromethaneHCID 70297m-Chloroperbenzoic acidHCID 68544628HCID 68544628, compound

Product 1

HCID 57731180HCID 57731180, compoundYield 95%

Procedure

10 mL dichloromethane solution was charged with 0.001 mol 1-(6-fluoro-2-(propylthio)benzo[d]thiazol-5-yl)-3,4-dimethyl-1H-1,2,4-triazol-5(4H)-one. The mixture was stirred for 10 mins and then 0.002 mol m-chloroperoxybenzoic acid (MCPBA) were added. After stirring at room temperature for 4 hours, the mixture was poured into 30 mL of water, extracted with 15 mL dichloromethane twice. Organic phases were combined and dried over anhydrous sodium sulfate. Filtration and removal of solvent under vacuum gave the title compound as a white solid in a 95% yield.

Workup

  1. stirringAfter stirring at room temperature for 4 hours
  2. extractionextracted with 15 mL dichloromethane twice
  3. dry with materialdried over anhydrous sodium sulfate
  4. filtrationFiltration and removal of solvent under vacuum

Sources & evidence

ORD record
ord-998d2d11f51f40b6b8b1104fd8032136
Source dataset
uspto-grants-2010_02
Patent number
US07666890B2

Reaction notes

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