Sodium Hydroxide → HCID 86614632, compound

HRID 1445754Notes

Reaction equation

HRID 1445754 reaction equation
C[O:2][C:3](=[O:27])[CH2:4][C:5]1[N:6]=[C:7]([C:11]2[CH:12]=[N:13][C:14]([C:17]3[CH:22]=[CH:21][C:20]([S:23]([CH3:26])(=[O:25])=[O:24])=[CH:19][CH:18]=3)=[CH:15][CH:16]=2)[O:8][C:9]=1[CH3:10].[OH-].[Na+:29]>CO.O1CCCC1>[CH3:26][S:23]([C:20]1[CH:19]=[CH:18][C:17]([C:14]2[N:13]=[CH:12][C:11]([C:7]3[O:8][C:9]([CH3:10])=[C:5]([CH2:4][C:3]([O-:27])=[O:2])[N:6]=3)=[CH:16][CH:15]=2)=[CH:22][CH:21]=1)(=[O:24])=[O:25].[Na+:29]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 58951478{2-[6-(4-Methanesulfonyl-phenyl)-pyridin-3-yl]-5-methyl-oxazol-4-yl}-acetic acid methyl ester2×

Product 1

HCID 86614632HCID 86614632, compound

Reagents, catalysts & solvents 1

HCID 21899815MeOH tetrahydrofuranSolvent

Procedure

To a stirring solution of {2-[6-(4-Methanesulfonyl-phenyl)-pyridin-3-yl]-5-methyl-oxazol-4-yl}-acetic acid methyl ester (See Intermediate 19) (1.0 mmol) in 1:1 methanol/tetrahydrofuran (0.10M), add 2N sodium hydroxide (1.2 mmol) and heat to reflux for 1 hour. After this time, concentrate the reaction in vacuo. Wash the resulting solid twice with dichloromethane to rinse away any impurities. MS (nme): 373.3 (M+1)

Workup

  1. temperatureheat
  2. temperatureto reflux for 1 hour
  3. concentrationAfter this time, concentrate
  4. customthe reaction in vacuo
  5. washWash the resulting solid twice with dichloromethane
  6. washto rinse away any impurities

Sources & evidence

ORD record
ord-0a5ca601f6db460eb6852089cb44698b
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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