Sodium Hydroxide → HCID 86614632, compound

Participants

Reaction Steps

To a stirring solution of {2-[6-(4-Methanesulfonyl-phenyl)-pyridin-3-yl]-5-methyl-oxazol-4-yl}-acetic acid methyl ester (See Intermediate 19) (1.0 mmol) in 1:1 methanol/tetrahydrofuran (0.10M), add 2N sodium hydroxide (1.2 mmol) and heat to reflux for 1 hour. After this time, concentrate the reaction in vacuo. Wash the resulting solid twice with dichloromethane to rinse away any impurities. MS (nme): 373.3 (M+1)

Provenance & Evidence