2-{5-Methyl-2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-oxazol-4-yl}-ethanol → 2-{2-[4-(6-Ethanesulfonyl-pyridin-3-yl)-phenyl]-5-methyl-oxazol-4-yl}-ethanol

HRID 1445756Notes

Reaction equation

HRID 1445756 reaction equation
[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][C:10](B3OC(C)(C)C(C)(C)O3)=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:22][CH2:23][OH:24].[CH2:25]([S:27]([C:30]1[CH:35]=[CH:34][C:33](I)=[CH:32][N:31]=1)(=[O:29])=[O:28])[CH3:26]>>[CH2:25]([S:27]([C:30]1[N:31]=[CH:32][C:33]([C:10]2[CH:9]=[CH:8][C:7]([C:5]3[O:6][C:2]([CH3:1])=[C:3]([CH2:22][CH2:23][OH:24])[N:4]=3)=[CH:12][CH:11]=2)=[CH:34][CH:35]=1)(=[O:28])=[O:29])[CH3:26]

Participants

3

Reactant 2

HCID 589514312-{5-Methyl-2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-oxazol-4-yl}-ethanol2×HCID 589514652-Ethanesulfonyl-5-iodo-pyridine2×

Product 1

HCID 589514262-{2-[4-(6-Ethanesulfonyl-pyridin-3-yl)-phenyl]-5-methyl-oxazol-4-yl}-ethanol

Procedure

The titled compound is prepared substantially in accordance with the procedure of Intermediate 9 using 2-{5-Methyl-2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-oxazol-4-yl}-ethanol (See Intermediate 3) and 2-Ethanesulfonyl-5-iodo-pyridine (See Intermediate 22). MS (m/e) 373.3 (M+1)

Sources & evidence

ORD record
ord-5785056c8c47432f93efb72a6c099329
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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