Hydrochloric Acid → 2-Amino-4-(benzyloxy)butanoic acid hydrochloride

HRID 1445760Notes

Reaction equation

HRID 1445760 reaction equation
[CH2:1]([O:8][CH2:9][CH2:10][CH:11]([NH:15]C(OC(C)(C)C)=O)[C:12]([OH:14])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:23].CCOCC>>[ClH:23].[NH2:15][CH:11]([CH2:10][CH2:9][O:8][CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[C:12]([OH:14])=[O:13]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 22458694Boc-DL-hse(bzl)-oh

Product 1

HCID 686989202-Amino-4-(benzyloxy)butanoic acid hydrochloride

Procedure

In a round bottom flask containing 4-benzyloxy-2-tert-butoxycarbonylamino-butyric acid (1.0 mmol), add 1M hydrochloric acid in ether (1.7 mmol) and stir at room temperature for two days. The product precipitates out as the hydrochloride salt. Collect by centrifugation in which the mother liquor is decanted off of the product. Rinse two times with ether, transfer solid to a flask and concentrate in vacuo.

Workup

  1. customThe product precipitates out as the hydrochloride salt
  2. customCollect by centrifugation in which the mother liquor
  3. customis decanted off of the product
  4. washRinse two times with ether, transfer solid to a flask
  5. concentrationconcentrate in vacuo

Sources & evidence

ORD record
ord-ac186f77adc843d68d7fef3c5e4ff15b
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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