反应详情

Add NBS (1.44 g, 8.08 mmol) to a solution of 2-(4-bromo-phenyl)-5-methyl-4-vinyl-oxazole (1.01 g, 4.02 mmol) in water (0.180 mL) and DMSO (30 mL). After 10 min add water and EtOAc. Separate the layers, extract aqueous material with EtOAc, and wash the crude organic extracts with water. Dry over MgSO4, filter and concentrate. Purify on silica gel eluting with 20% EtOAc/Hexanes to give the title compound (1.08 g, 74%): MS (m/e): 362 (M+1).

1. customSeparate the layers
2. extractionextract aqueous material with EtOAc
3. washwash the crude organic extracts with water
4. dry with materialDry over MgSO4
5. filtrationfilter
6. concentrationconcentrate
7. customPurify on silica gel eluting with 20% EtOAc/Hexanes