HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl (3R)-3-(hydroxymethyl)pyrrolidine-1-carboxylate → (R)-tert-Butyl 3-(fluoromethyl)-pyrrolidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl (3R)-3-(hydroxymethyl)pyrrolidine-1-carboxylate | HCID 1514340 | — |
| Reactant | (Bis(2-methoxyethyl)amino)sulfur trifluoride | HCID 2734690 | — |
| Reactant | tert-Butyl (3S)-3-fluoropyrrolidine-1-carboxylate | HCID 18453464 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (R)-tert-Butyl 3-(fluoromethyl)-pyrrolidine-1-carboxylate | HCID 58951460 | — |
Reaction Steps
Prepare using the method of Intermediate 48 with (R)-N-Boc-pyrrolidine-3-methanol (0.50 g, 2.48 mmol), [bis(2-methoxyethyl)amino]sulfur trifluoride (0.55 mL, 2.98 mmol) and anhydrous dichloromethane (2.5 mL) to give the title compound as a colourless oil (0.34 g): MS (m/e): 226 (M+23).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07666871B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-7c4b8b66d23646699386e2d25400c06e |
| Source note | uspto-grants-2010_02 |