4-(Chloromethyl)-1,3-thiazole hydrochloride → HCID 58951447, compound

HRID 1445782Notes

Reaction equation

HRID 1445782 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:22])=[C:11]([CH2:13][C:14]([N:16]3[CH2:20][CH2:19][CH2:18][C@H:17]3[CH3:21])=[O:15])[N:12]=2)=[CH:4][CH:3]=1.Cl.Cl[CH2:25][C:26]1[N:27]=[CH:28][S:29][CH:30]=1>>[CH3:21][C@@H:17]1[CH2:18][CH2:19][CH2:20][N:16]1[C:14](=[O:15])[CH2:13][C:11]1[N:12]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]([O:1][CH2:25][C:26]3[N:27]=[CH:28][S:29][CH:30]=3)=[CH:3][CH:4]=2)[O:9][C:10]=1[CH3:22]

Participants

3

Reactant 2

HCID 27632894-(Chloromethyl)-1,3-thiazole hydrochlorideHCID 135487319HCID 135487319, compound2×

Product 1

HCID 58951447HCID 58951447, compound

Procedure

The title compound is prepared in a manner substantially similar to Intermediate 16 from 2-[2-(4-Hydroxy-phenyl)-5-methyl-oxazol-4-yl]-1-(2-(R)-methyl-pyrrolidin-1-yl)-ethanone (See Intermediate 62) and 4-(chloromethyl)thiazole hydrochloride except KI (1.5 eq.) is also added. MS (ES+) 398.3

Workup

  1. additionis also added

Sources & evidence

ORD record
ord-a6b26266c827410eb67c942c71949816
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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