Hydrochloric Acid → N-[4'-(4-Pyrrolidin-1-ylmethyl-oxazol-2-yl)-biphenyl-4-yl]-methanesulfonamide

HRID 1445790Notes

Reaction equation

HRID 1445790 reaction equation
[CH3:1][S:2]([NH:5][C:6]1[CH:11]=[CH:10][C:9](B(O)O)=[CH:8][CH:7]=1)(=[O:4])=[O:3].Br[C:16]1[CH:21]=[CH:20][C:19]([C:22]2[O:23][CH:24]=[C:25]([CH2:27][N:28]3[CH2:32][CH2:31][CH2:30][CH2:29]3)[N:26]=2)=[CH:18][CH:17]=1.Cl>>[N:28]1([CH2:27][C:25]2[N:26]=[C:22]([C:19]3[CH:20]=[CH:21][C:16]([C:9]4[CH:10]=[CH:11][C:6]([NH:5][S:2]([CH3:1])(=[O:4])=[O:3])=[CH:7][CH:8]=4)=[CH:17][CH:18]=3)[O:23][CH:24]=2)[CH2:29][CH2:30][CH2:31][CH2:32]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 2773537(4-Methanesulfonamidophenyl)boronic acidHCID 11681084HCID 11681084, compound

Product 1

HCID 11689799N-[4'-(4-Pyrrolidin-1-ylmethyl-oxazol-2-yl)-biphenyl-4-yl]-methanesulfonamide

Procedure

The titled compound is prepared substantially in accordance with the procedure of Example 4 using 4-(methylsulfonylamino)phenylboronic acid and 2-(4-Bromo-phenyl-4-pyrrolidin-1-ylmethyl-oxazole; hydrochloride (See Example 2). MS (m/e) 398.2 (M+1)

Sources & evidence

ORD record
ord-f04816213b004d1ea0663bb88ed4190b
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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