Hydrochloric Acid → (+/-)-3-{4-[4-(2-Methyl-piperidin-1-ylmethyl)-oxazol-2-yl]-phenyl}-pyridine dihydrochloride salt

HRID 1445794Notes

Reaction equation

HRID 1445794 reaction equation
[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][N:3]1[CH2:8][C:9]1[N:10]=[C:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=3)=[CH:16][CH:15]=2)[O:12][CH:13]=1.[ClH:26]>ClCCl.C(OCC)C>[ClH:26].[ClH:26].[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][N:3]1[CH2:8][C:9]1[N:10]=[C:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=3)=[CH:16][CH:15]=2)[O:12][CH:13]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 11537304(+/-)-3-{4-[4-(2-Methyl-piperidin-1-ylmethyl)-oxazol-2-yl]-phenyl}-pyridine

Product 1

HCID 69468390(+/-)-3-{4-[4-(2-Methyl-piperidin-1-ylmethyl)-oxazol-2-yl]-phenyl}-pyridine dihydrochloride salt

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

Dissolve 3-{4-[4-(2-Methyl-piperidin-1-ylmethyl)-oxazol-2-yl]-phenyl}-pyridine (See Example 22) in minimal dichloromethane and add 1M hydrochloric acid in diethyl ether until the solution is cloudy. Add hexane and concentrate in vacuo to yield the titled compound. MS (m/e): 334.1 (M+1)

Workup

  1. concentrationAdd hexane and concentrate in vacuo

Sources & evidence

ORD record
ord-a42a2ab629364aa1829b71fa13e3ca2d
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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