4-(Methanesulfonyl)phenylboronic acid → 2-(4'-Methanesulfonyl-biphenyl-4-yl)-5-methyl-4-(2-pyrrolidin-1-yl-ethyl)-oxazole

HRID 1445795Notes

Reaction equation

HRID 1445795 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:20])=[C:11]([CH2:13][CH2:14][N:15]3[CH2:19][CH2:18][CH2:17][CH2:16]3)[N:12]=2)=[CH:4][CH:3]=1.[CH3:21][S:22]([C:25]1[CH:30]=[CH:29][C:28](B(O)O)=[CH:27][CH:26]=1)(=[O:24])=[O:23]>>[CH3:21][S:22]([C:25]1[CH:30]=[CH:29][C:28]([C:2]2[CH:7]=[CH:6][C:5]([C:8]3[O:9][C:10]([CH3:20])=[C:11]([CH2:13][CH2:14][N:15]4[CH2:19][CH2:18][CH2:17][CH2:16]4)[N:12]=3)=[CH:4][CH:3]=2)=[CH:27][CH:26]=1)(=[O:24])=[O:23]

Participants

3

Reactant 2

HCID 27343644-(Methanesulfonyl)phenylboronic acidHCID 116815462-(4-Bromo-phenyl)-5-methyl-4-(2-pyrrolidin-1-yl-ethyl)-oxazole

Product 1

HCID 115605942-(4'-Methanesulfonyl-biphenyl-4-yl)-5-methyl-4-(2-pyrrolidin-1-yl-ethyl)-oxazole

Procedure

Starting with 2-(4-Bromo-phenyl)-5-methyl-4-(2-pyrrolidin-1-yl-ethyl)-oxazole (See Example 8) and 4-methylsulfonylphenylboronic acid, follow a procedure significantly analogous to that found in Example 22 to give the titled compound. MS (m/e): 411.2 (M+1)

Sources & evidence

ORD record
ord-4e52a9de71f041b6b4d6d05881eb067d
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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