2-Methylpyrrolidine → HCID 58951495, compound

HRID 1445799Notes

Reaction equation

[CH2:1]([O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[O:13][C:14]([CH3:30])=[C:15]([CH2:17][CH2:18]OS(C3C=CC(C)=CC=3)(=O)=O)[N:16]=2)=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH3:4].[CH3:31][CH:32]1[CH2:36][CH2:35][CH2:34][NH:33]1>>[CH2:1]([O:5][C:6]1[CH:7]=[CH:8][C:9]([C:12]2[O:13][C:14]([CH3:30])=[C:15]([CH2:17][CH2:18][N:33]3[CH2:34][CH2:35][CH2:36][CH:32]3[CH3:31])[N:16]=2)=[CH:10][CH:11]=1)[CH2:2][CH2:3][CH3:4]

Participants

Reactant 2

HCID 130032-Methylpyrrolidine

HCID 58979246HCID 58979246, compound

Product 1

HCID 58951495HCID 58951495, compound

Procedure

Starting with Toluene-4-sulfonic acid 2-[2-(4-butoxy-phenyl)-5-methyl-oxazol-4-yl]-ethyl ester [CAS 478540-91-9] and racemic 2-methylpyrrolidine, follow procedures significantly analogous to Example 8 to provide the free base of the titled compound. The free base is converted to the titled compound significantly in accordance with the procedure of Example 23. MS (m/e): 343.3 (M+1)

Sources & evidence

ORD record: ord-045719b76a6245558088d81e7fffde2d
Source dataset: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07666871B2

Reaction notes

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