(4-Methoxyphenyl)boronic acid → 2-(4'-Methoxy-biphenyl-4-yl)-5-methyl-4-(2-pyrrolidin-1-yl-ethyl)-oxazole

HRID 1445804Notes

Reaction equation

HRID 1445804 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6](B(O)O)=[CH:5][CH:4]=1.Br[C:13]1[CH:18]=[CH:17][C:16]([C:19]2[O:20][C:21]([CH3:31])=[C:22]([CH2:24][CH2:25][N:26]3[CH2:30][CH2:29][CH2:28][CH2:27]3)[N:23]=2)=[CH:15][CH:14]=1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:13]2[CH:18]=[CH:17][C:16]([C:19]3[O:20][C:21]([CH3:31])=[C:22]([CH2:24][CH2:25][N:26]4[CH2:27][CH2:28][CH2:29][CH2:30]4)[N:23]=3)=[CH:15][CH:14]=2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 201262(4-Methoxyphenyl)boronic acidHCID 116815462-(4-Bromo-phenyl)-5-methyl-4-(2-pyrrolidin-1-yl-ethyl)-oxazole

Product 1

HCID 116029772-(4'-Methoxy-biphenyl-4-yl)-5-methyl-4-(2-pyrrolidin-1-yl-ethyl)-oxazole

Procedure

The title compound is prepared in a manner substantially analogous to Example 35 starting from 4-Methoxybenzene boronic acid and 2-(4-Bromo-phenyl)-5-methyl-4-(2-pyrrolidin-1-yl-ethyl)-oxazole. MS (m/e): 363.2 (M+1)

Sources & evidence

ORD record
ord-3bb7351c98ba466288df9c3a714892d0
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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