4-(Ethylsulphonyl)benzeneboronic acid → 2-(4'-Ethanesulfonyl-biphenyl-4-yl)-5-methyl-4-(2-pyrrolidin-1-yl-ethyl)-oxazole

HRID 1445809Notes

Reaction equation

HRID 1445809 reaction equation
[CH2:1]([S:3]([C:6]1[CH:11]=[CH:10][C:9](B(O)O)=[CH:8][CH:7]=1)(=[O:5])=[O:4])[CH3:2].Br[C:16]1[CH:21]=[CH:20][C:19]([C:22]2[O:23][C:24]([CH3:34])=[C:25]([CH2:27][CH2:28][N:29]3[CH2:33][CH2:32][CH2:31][CH2:30]3)[N:26]=2)=[CH:18][CH:17]=1>>[CH2:1]([S:3]([C:6]1[CH:11]=[CH:10][C:9]([C:16]2[CH:21]=[CH:20][C:19]([C:22]3[O:23][C:24]([CH3:34])=[C:25]([CH2:27][CH2:28][N:29]4[CH2:30][CH2:31][CH2:32][CH2:33]4)[N:26]=3)=[CH:18][CH:17]=2)=[CH:8][CH:7]=1)(=[O:5])=[O:4])[CH3:2]

Participants

3

Reactant 2

HCID 27734204-(Ethylsulphonyl)benzeneboronic acidHCID 116815462-(4-Bromo-phenyl)-5-methyl-4-(2-pyrrolidin-1-yl-ethyl)-oxazole

Product 1

HCID 115826382-(4'-Ethanesulfonyl-biphenyl-4-yl)-5-methyl-4-(2-pyrrolidin-1-yl-ethyl)-oxazole

Procedure

The title compound is prepared in a mamler substantially analogous to Example 35 starting from 4-Ethylsulfonylbenzene boronic acid and 2-(4-Bromo-phenyl)-5-methyl-4-(2-pyrrolidin-1-yl-ethyl)-oxazole. MS (m/e): 425.1 (M+1)

Sources & evidence

ORD record
ord-bdcf9a77df06423a9b852100acf9523f
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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