Ethanol → HCID 135487319, compound

HRID 1445822Notes

Reaction equation

HRID 1445822 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[O:16][C:17]([CH3:28])=[C:18]([CH2:20][CH2:21][N:22]3[CH2:26][CH2:25][CH2:24][C@H:23]3[CH3:27])[N:19]=2)=[CH:11][CH:10]=1)C1C=CC=CC=1.C([OH:31])C>[Pd]>[OH:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[O:16][C:17]([CH3:28])=[C:18]([CH2:20][C:21]([N:22]3[CH2:26][CH2:25][CH2:24][C@H:23]3[CH3:27])=[O:31])[N:19]=2)=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 702EthanolHCID 11494564HCID 11494564, compound

Product 1

HCID 135487319HCID 135487319, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A mixture of 2-(4-Benzyloxy-phenyl)-5-methyl-4-[2-(2-(R)-methyl-pyrrolidin-1-yl)-ethyl]-oxazole (See Example 55) (0.48 g, 1.3 mmol) and 5% Pd/C (0.046 g) in absolute ethanol (25 mL) is shaken under a hydrogen atmosphere (65 psi) for 18 h. The mixture is filtered and concentrated to provide the title compound (0.35 g, 94%) as a yellow oil, which was used without purification. MS (m/e): 287.3 (M+1)

Workup

  1. filtrationThe mixture is filtered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-5ada5fd47c124c37ad9511a4e1c6eb63
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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