Methanesulfonic acid 2-[2-(4-bromo-phenyl)-5-methyl-oxazol-4-yl]-ethyl ester → 2-(3-Fluoro-4'-methanesulfonyl-biphenyl-4-yl)-5-methyl-4-[2-(2-methyl-pyrrolidin-1-yl)-ethyl]-oxazole

HRID 1445833Notes

Reaction equation

HRID 1445833 reaction equation
BrC1C=CC([C:8]2O[C:10](C)=[C:11]([CH2:13][CH2:14]OS(C)(=O)=O)[N:12]=2)=CC=1.[F:21][C:22]1[CH:23]=[C:24]([C:37]2[CH:42]=[CH:41][C:40]([S:43]([CH3:46])(=[O:45])=[O:44])=[CH:39][CH:38]=2)[CH:25]=[CH:26][C:27]=1[C:28]1[O:29][C:30]([CH3:36])=[C:31]([CH2:33][CH2:34]O)[N:32]=1>>[F:21][C:22]1[CH:23]=[C:24]([C:37]2[CH:38]=[CH:39][C:40]([S:43]([CH3:46])(=[O:45])=[O:44])=[CH:41][CH:42]=2)[CH:25]=[CH:26][C:27]=1[C:28]1[O:29][C:30]([CH3:36])=[C:31]([CH2:33][CH2:34][N:12]2[CH2:8][CH2:14][CH2:13][CH:11]2[CH3:10])[N:32]=1

Participants

3

Reactant 2

HCID 11451238Methanesulfonic acid 2-[2-(4-bromo-phenyl)-5-methyl-oxazol-4-yl]-ethyl esterHCID 589514052-[2-(3-Fluoro-4'-methanesulfonyl-biphenyl-4-yl)-5-methyl-oxazol-4-yl]-ethanol2×

Product 1

HCID 116264032-(3-Fluoro-4'-methanesulfonyl-biphenyl-4-yl)-5-methyl-4-[2-(2-methyl-pyrrolidin-1-yl)-ethyl]-oxazole

Procedure

The titled compound is prepared in substantial accordance with the procedures found in Intermediate 13 and Example 75 using 2-[2-(3-Fluoro-4′-methanesulfonyl-biphenyl-4-yl)-5-methyl-oxazol-4-yl]-ethanol (see Intermediate 38). MS (m/e): 443.3 (M+1)

Sources & evidence

ORD record
ord-84e5dd3b172241f982ca29dc42bdedbe
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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