Methanesulfonic acid 2-[2-(4-bromo-phenyl)-5-methyl-oxazol-4-yl]-ethyl ester → 2-(3-Fluoro-4'-methanesulfonyl-biphenyl-4-yl)-5-methyl-4-[2-(2-methyl-pyrrolidin-1-yl)-ethyl]-oxazole

Participants

Role	Name	HCID	Charge
Reactant	Methanesulfonic acid 2-[2-(4-bromo-phenyl)-5-methyl-oxazol-4-yl]-ethyl ester	HCID 11451238	—
Reactant	2-[2-(3-Fluoro-4'-methanesulfonyl-biphenyl-4-yl)-5-methyl-oxazol-4-yl]-ethanol	HCID 58951405	—
Product	2-(3-Fluoro-4'-methanesulfonyl-biphenyl-4-yl)-5-methyl-4-[2-(2-methyl-pyrrolidin-1-yl)-ethyl]-oxazole	HCID 11626403	—

Reaction Steps

The titled compound is prepared in substantial accordance with the procedures found in Intermediate 13 and Example 75 using 2-[2-(3-Fluoro-4′-methanesulfonyl-biphenyl-4-yl)-5-methyl-oxazol-4-yl]-ethanol (see Intermediate 38). MS (m/e): 443.3 (M+1)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07666871B2
Source dataset	uspto-grants-2010_02
ORD ID	ord-84e5dd3b172241f982ca29dc42bdedbe
Source note	uspto-grants-2010_02