(4-Methoxyphenyl)boronic acid → HCID 11610516, compound

HRID 1445876Notes

Reaction equation

HRID 1445876 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6](B(O)O)=[CH:5][CH:4]=1.Br[C:13]1[CH:18]=[CH:17][C:16]([C:19]2[O:20][C:21]([CH3:32])=[C:22]([CH2:24][CH2:25][N:26]3[CH2:30][CH2:29][CH2:28][C@H:27]3[CH3:31])[N:23]=2)=[CH:15][CH:14]=1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:13]2[CH:18]=[CH:17][C:16]([C:19]3[O:20][C:21]([CH3:32])=[C:22]([CH2:24][CH2:25][N:26]4[CH2:30][CH2:29][CH2:28][C@H:27]4[CH3:31])[N:23]=3)=[CH:15][CH:14]=2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 201262(4-Methoxyphenyl)boronic acidHCID 11530378HCID 11530378, compound

Product 1

HCID 11610516HCID 11610516, compound

Procedure

The title compound is prepared in a manner substantially analogous to example 133 starting from 4-methoxybenzene boronic acid (218 mg, 1.43 mmol) and 2-(4-Bromo-phenyl)-5-methyl-4-[2-((R)-2-methyl-pyrrolidin-1-yl)-ethyl]-oxazole (100 mg, 0.287 mmol) to give 61 mg (56%). MS (m/e) 377.2 (M+1)

Workup

  1. customto give 61 mg (56%)

Sources & evidence

ORD record
ord-f4da1fb8f62740639e47c894f9651ef9
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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