Phenylboronic Acid → HCID 58951419, compound

HRID 1445880Notes

Reaction equation

HRID 1445880 reaction equation
[C:1]1(B(O)O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[C:11]1[CH:16]=[CH:15][C:14]([C:17]2[O:18][C:19]([CH3:30])=[C:20]([CH2:22][CH2:23][N:24]3[CH2:28][CH2:27][CH2:26][C@H:25]3[CH3:29])[N:21]=2)=[CH:13][CH:12]=1>>[C:11]1([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH:16]=[CH:15][C:14]([C:17]2[O:18][C:19]([CH3:30])=[C:20]([CH2:22][CH2:23][N:24]3[CH2:28][CH2:27][CH2:26][C@H:25]3[CH3:29])[N:21]=2)=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 66827Phenylboronic AcidHCID 11530378HCID 11530378, compound

Product 1

HCID 58951419HCID 58951419, compound

Procedure

The title compound is prepared in a manner substantially analogous to example 133 starting from phenyl boronic acid (174 mg, 1.43 mmol) and 2-(4-Bromo-phenyl)-5-methyl-4-[2-((R)-2-methyl-pyrrolidin-1-yl)-ethyl]-oxazole (100 mg, 0.287 mmol) to give 16 mg (16%). MS (m/e) 347.3 (M+1)

Workup

  1. customto give 16 mg (16%)

Sources & evidence

ORD record
ord-9b5e68b8dcc84ba68b449ed90c915b23
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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