4-(Trifluoromethoxy)phenylboronic acid → HCID 58951459, compound

HRID 1445886Notes

Reaction equation

HRID 1445886 reaction equation
[F:1][C:2]([F:14])([F:13])[O:3][C:4]1[CH:9]=[CH:8][C:7](B(O)O)=[CH:6][CH:5]=1.Br[C:16]1[CH:21]=[CH:20][C:19]([C:22]2[O:23][C:24]([CH3:35])=[C:25]([CH2:27][CH2:28][N:29]3[CH2:33][CH2:32][CH2:31][C@H:30]3[CH3:34])[N:26]=2)=[CH:18][CH:17]=1>>[CH3:35][C:24]1[O:23][C:22]([C:19]2[CH:20]=[CH:21][C:16]([C:7]3[CH:8]=[CH:9][C:4]([O:3][C:2]([F:14])([F:13])[F:1])=[CH:5][CH:6]=3)=[CH:17][CH:18]=2)=[N:26][C:25]=1[CH2:27][CH2:28][N:29]1[CH2:33][CH2:32][CH2:31][C@H:30]1[CH3:34]

Participants

3

Reactant 2

HCID 27343864-(Trifluoromethoxy)phenylboronic acidHCID 11530378HCID 11530378, compound

Product 1

HCID 58951459HCID 58951459, compound

Procedure

The title compound is prepared in a manner substantially analogous to example 133 starting from 4-triflouromethoxy phenyl boronic acid (295 mg, 1.43 mmol) and 2-(4-Bromo-phenyl)-5-methyl-4-[2-((R)-2-methyl-pyrrolidin-1-yl)-ethyl]-oxazole (100 mg, 0.287 mmol) to give 63 mg (51%). MS (m/e) 431.2 (M+1)

Workup

  1. customto give 63 mg (51%)

Sources & evidence

ORD record
ord-bd7e9d2d0bd54113bec350288f128e54
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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