反应详情

A mixture of 4-hydroxy-2-methylindole (1) (1.5 g, 0.010 mole), 2-bromo-3-methyl-butyric acid ethyl ester (2.2 g, 0.010 mole) and potassium carbonate (excess) in acetone (50 mL) was refluxed for 3 days. The reaction mixture was filtered, and the filtrate was concentrated. The residue was purified by column chromatography (20:1 Hex:EtOAc) to afford intermediate 2. Yield: 1.88 g, 71%

1. temperaturewas refluxed for 3 days
2. filtrationThe reaction mixture was filtered
3. concentrationthe filtrate was concentrated
4. customThe residue was purified by column chromatography (20:1 Hex:EtOAc)