反应详情

1-(biphenyl-2-ylmethyl)-2-ethyl-1H-pyrrole, 13: To the crude 12 (14 g, 83 mmol) in dry benzene (200 mL) at room temperature is added biphenyl-2-ylmethanamine solution (100 mmol) and triethylamine (110 mmol). The solution is heated to reach 65° C. and stirred for 18 h. The resulted reaction mixture is filtered and concentrated. The crude product was purified by silica gel chromatography to afford 13

1. temperatureThe solution is heated
2. customto reach 65° C.
3. customThe resulted reaction mixture
4. filtrationis filtered
5. concentrationconcentrated
6. customThe crude product was purified by silica gel chromatography