Acetic Anhydride → HCID 10633517, compound

HRID 1445958Notes

Reaction equation

HRID 1445958 reaction equation
[C:1](OC(=O)C)(=[O:3])C.[NH2:8][C:9]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)([CH2:15][CH3:16])[C:10]([O:12][CH2:13][CH3:14])=[O:11]>C(O)=O>[CH:1]([NH:8][C:9]([C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1)([CH2:15][CH3:16])[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[O:3]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 10488547ethyl 2-amino-2-phenylbutanoate

Product 1

HCID 10633517HCID 10633517, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

12.72 mL of formic acid then 25.38 mL of acetic anhydride were added dropwise, under stirring, to 2.49 g (12.03 mmol) of amine 6. After 15 h at room temperature, solvents were removed under reduced pressure to give 3.09 g of 7 as a green viscous oil (100% yield).

Workup

  1. customsolvents were removed under reduced pressure

Sources & evidence

ORD record
ord-2da4ae924bff4504b561554cb1a035c5
Source dataset
uspto-grants-2010_02
Patent number
US07666907B2

Reaction notes

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