反应详情

272.13 g of a 40% solution of choline hydroxide and 145.73 g of 2-ethylhexanoic acid were stirred vigorously for 30 min at RT in a glass flask with reflux condenser, heatable oil bath, mechanical stirrer and internal thermometer. Water and methanol were distilled off in a rotary evaporator at 30-45° C. under a vacuum increased gradually to 20 mbar. The product was then taken up in n-hexane and re-evaporated in the rotary evaporator and dried at 0.1 mbar and 40° C. for 2 h, giving a slightly colored, viscous liquid whose 1H-NMR spectrum showed equi-molar ratios of choline and ethylhexanoate, but only a weak signal in the region of aliphatic carboxylic acids.

1. temperaturewith reflux condenser, heatable oil bath, mechanical stirrer
2. distillationWater and methanol were distilled off in a rotary evaporator at 30-45° C. under a vacuum
3. temperatureincreased gradually to 20 mbar
4. customre-evaporated in the rotary evaporator
5. customdried at 0.1 mbar and 40° C. for 2 h
6. customgiving a slightly colored, viscous liquid whose 1H-NMR spectrum